First scientific publication Ser-Col in Acta Tropica – Elsevier

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We are pleased to announce the publication ‘Automated and combined HIV, HBV, HCV, and syphilis testing among illegal gold miners in French Guiana using a standardised dried blood device’ in the journal Acta Tropica.

In this publication, Professor Edouard Tuaillon of the Institute of Molecular Genetics of Montpellier (Institut de Génétique Moléculaire de Montpellier (IGMM)) describes the use of the Labonovum Ser-Col blood collection device in comparison with plasma results and DBS results in a study of HIV, HBV, and syphilis among illegal gold miners in French Guiana.

The researchers established a complete concordance of Ser-Col and DBS results for HIV diagnosis compared with plasma results. Ser-Col facilitates large-scale surveys and improves testing of populations living in remote areas.

Interested in reading the entire publication:

https://authors.elsevier.com/c/1g6WL,2UvtImB

 

 

Automated and combined HIV, HBV, and syphilis testing among illegal gold miners in French Guiana using a standardized dried blood device

 

Caption: Results of HIV, hepatitis B and hepatitis C testing on Ser-Col and DBS samples. A) Results of HIV testing in Ser-Col samples and dried blood spot (DBS) according to HIV status in sera. B) Results of HBsAg testing in Ser-Col samples and dried blood spot (DBS) according to HBsAg status in sera. C) Results of hepatitis C antibody testing in Ser-Col samples and dried blood spot (DBS) according to anti-HCV status in sera. All samples tested positive for anti-HCV antibodies were negative for HCV RNA.

 

 

Caption: Anti-treponemal antibody results in Ser-Col and Dried Blood Spot samples. A) Anti-treponemal antibodies in Ser-Col samples and dried blood spot (DBS) according to syphilis serological status in plasma; dotted line: threshold of the manufactuer; solid line: optimized threshold for Ser-Col and DBS samples. B) Receiver operating characteristic curve (ROC) evaluating anti-treponemal antibody detection in Ser-Col samples. C) ROC evaluating anti-treponemal antibody detection in DBS samples.

Validation procedure of SCAUT

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Start with validation procedure of SCAUT for serology testing in collaboration with Streeklab Haarlem and Elisabeth-TweeSteden hospital in Tilburg.

650 SCAUT devices

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First 650 SCAUT devices received from Centre Hospitalier Université Montpellier and processed with the SCAUT.

750 Scaut devices

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First 750 SCAUT devices received from Yerevan State Medical University and processed with the SCAUT.

Ser-Col Instructions For Use

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The instructions for use (IFU) have been produced by video. See this movie that will be provided in different languages.

Impression of the SCAUT processing steps

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The first few hundred Ser-Cols are being processed by SCAUT. See this movie for an impression of the different processing steps. Some minor adjustments were necessary to improve the throughput and reduce the turn around time (TAT) to 24 seconds.

See this article in the newspaper about Ser-Col and Corona testing.

Labonovum has received the first SCAUT (Ser-Col AUTomation) from Blok System Supply (BSS).

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The last 18 months both Labonovum and BSS has worked intensively on the development of a dried serum spot automated processing solution. From stable dried serum on lateral flow paper to liquid serum in less than 30 seconds!
The coming months will be used to validate SCAUT for processing of dried serum spots for infectious diseases, such as corona.

The second out of tools

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The second out of tools have arrived! The coming months these Ser-Cols will be tested extensively in both patient user friendliness as well as automated processing by SCAUT.

Scaut FOT

The “first out of tools” (FOTs)

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The “first out of tools” (FOTs) is the first production from the mold. With these FOTs we have determined the position of the fill level indicator. The fill level indicator is an opening in the Ser-Col just above the LF paper. Once the blood flows through the fill level indicator, the collected amount of blood is sufficient for testing. Some other minor changes were applied for an optimal automated Ser-Col processing in SCAUT.

Labonovum Mold Production

Ser-Col Mold production is Finished

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The 7 different parts of Ser-Col are being produced by plastic molding. Liquid plastic is injected under high pressure and high temperature into a steel mold (see pictures). After fast cooling by so-called cooling channel the mold is opened and the plastic parts are released from the mold. After closing, the mold is ready for the next molding step.